Year: 2002
Type: article
Study design: Clinical Trial
Abstract: Six patients with well-documented histories of seasonal allergic rhinitis caused by Japanese cedar pollen were allocated randomly on a single-blind basis to receive either sublingual immunotherapy (SL-IT) with a solution of purified allergen preparation (Hollister Stier) or a matched placebo for 24 weeks from 1998 to 1999. The SL-IT effect was assessed based on the symptom medication score (SMS). Actively treated patients tended to have a lower SMS during the pollen season than the placebo group. The same six patients were treated by active allergen from 1999 to 2000. SMS of these patients was compared to the SMS of matched patients treated by medication alone. SL-IT-treated patients had lower SMS during the 3 weeks of the pollen season than the medication group. Side-effects were negligible.The stimulatory index (SI) of PBMC by antigen stimulation was also studied to determine the SL-IT mechanism in the first experiment. The SI of 2 patients in the actively treated group rose early in the pollen season. The SI in the placebo group did not, however, indicating the effectiveness of SL-IT related to general immunization. We concluded that SL-IT with Japanese cedar pollen extract in patients with Japanese cedar pollinosis is as effective as when used overseas.
Institutions: Nippon Medical School, Meiji (Japan)
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2322374146