Work

Platelet Hyperreactivity: Report of a Case with Catastrophic Arterial Thrombosis in a Child

Year: 2012

Type: article

Abstract: Platelet hyperreactivity is an important but under-recognized cause of idiopathic arterial thrombosis. We describe a case of arterial thrombosis in a previously healthy 12-year-old girl after minor trauma to the knee, resulting in lower extremity amputation. Family history was positive for arterial and venous thrombosis, but an extensive work-up for the usual inherited thrombophilia risk factors was negative. The patient was eventually diagnosed with platelet hyperreactivity and remains on life-long antiplatelet therapy.Consideration of platelet hyperreactivity in the evaluation of unusual arterial thrombotic events allows for targeted therapy, potential avoidance of future events, and timely screening of family members.

Source: Laboratory Hematology

DOI: 10.1532/lh96.12006

Authors: Elizabeth F. Plocharczyk, Sarah H. O'Brien, Jill L. Crumbacher, Samir B. Kahwash

Institution: The Ohio State University

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2322755070

FWCI:

Cites: 12

Cited by:

Related to: 10