Work

The Aurora Kinase A Polymorphisms are not Associated with Recurrence-free Survival in Prostate Cancer Patients

Year: 2012

Type: article

Abstract: Background: The purpose of this study was to investigate the association between haplotype-tagging single nucleotide polymorphisms (SNPs) within the Aurora Kinase A (AURKA) gene and prostate cancer outcomes in patients with clinically localized prostate cancer.Methods: Four intronic haplotype-tagging SNPs within the AURKA gene were individually selected and examined in regard to their influence on clinical outcomes in 212 patients who underwent radical prostatectomy as first-line treatment.Haplotype-tagging SNPs were selected using the ABI SNP Browser to cover SNPs with an r 2 of 0.90 or greater in the AURKA gene with a minor allele frequency of at least 0.25.Results: In our study, a log-rank univariate analysis was performed to identify significant associations between probability of recurrence-free survival or disease-free survival and known prognostic indicators as well as AURKA genotypes.The prognostic indicators Gleason grade, surgical margin, extracapsular extension, and disease stage were associated with recurrence-free survival (all p<0.001).Only Gleason grade was associated with disease-free survival (p<0.001).No associations were found for the SNPs rs1468055, rs8117896, rs2064863, and rs1468056 analyzed for either RFS (p=0.7213,p=0.5140, p=0.0714, p=0.4731, respectively) or DFS (p=0.3282,p=0.

Source: Journal of Cancer Science & Therapy

DOI: 10.4172/1948-5956.1000105

Authors: Jerry J. Jaboin, Natalie L. Ausborn,, Misun Hwang,, Heidi Chen

Institution: Vanderbilt University

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Vanderbilt Institute for Clinical and Translational Research, Georgia Clinical and Translational Science Alliance