Work

BOS after HCT: Preceding Events, Diagnostic Characteristics, and Natural History of Patients Treated on a Prospective Trial

Year: 2015

Type: article

Abstract: Bronchiolitis obliterans syndrome (BOS) is a serious late complication of allogeneic hematopoietic cell transplantation (HCT) with poorly characterized risk factors and natural history due to disease rarity. We describe the prevalence of potential risk factors, diagnostic characteristics, and natural history of 36 individuals enrolled on a multicenter prospective trial (NCT01307462) to treat new onset BOS after HSCT. BOS was diagnosed using modified 2005 NIH consensus criteria (FEV1<75% predicted, FEV1/VC<0.7, and >10% FEV1 decline from pre-HCT).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2014.11.253

Authors: Guang-Shing Cheng, Iskra Pusic, Madan H. Jagasia, Linda J. Burns, Vincent T. Ho, Joseph Pidala, Jeanne Palmer, Laura Johnston, Sebastian Mayer, Xiaoyu Chai, Stephanie J. Lee, Kirsten M. Williams

Institutions: University of Washington, Fred Hutch Cancer Center, Washington University Medical Center, Vanderbilt University Medical Center, National Marrow Donor Program, Dana-Farber Cancer Institute, Moffitt Cancer Center, Mayo Clinic in Arizona, Mayo Clinic Hospital, Mayo Clinic Comprehensive Cancer Center (Arizona), Stanford Medicine, Stanford University, Weill Cornell Medicine, Weill Cornell Medical Center, National Institutes of Health, National Cancer Institute

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650

OpenAlex ID: W2322992231

FWCI:

Cites:

Cited by: 1

Related to: 10