Plasma cytokines and chemokines differentiate between active and non-active tuberculosis infection
Year: 2013
Type: article
Abstract: Event Abstract Back to Event Plasma cytokines and chemokines differentiate between active and non-active tuberculosis infection Adane Mihret1, 2*, Yonas Bekele1, Kidist Bobosha1, Marthin Kidd3, Abraham Aseffa1, Rawleigh Howe1 and Gerhard Walzl2 1 Armauer Hansen Research Institute, Ethiopia 2 DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 19063, Francie van Zijl Drive, Tygerberg 7505, South Africa, South Africa 3 Centre for Statistical Consultation, Department of Statistics and Actuarial Sciences, Faculty of Science, University of Stellenbosch, South Africa, South Africa Abstract Identifying biomarkers that could differentiate between the different clinical conditions of M. tuberculosis infection and treatment outcomes have paramount importance in TB control. We analysed ex vivo plasma samples from 33 TB patients (17 HIV negative and 16 HIV positive) and 30 healthy household contacts with Luminex. We found a statistically significant difference (p<0.05) in median plasma level of EGF, fractalkine, IFN-gamma, IL-4, MCP-3 and IP-10 between contacts and TB patients. However, none of the cytokines were significantly different in latently infected and uninfected contacts (P>0.05). HIV does not affect the median plasma level of any of the cytokine or chemokine and there was not significant difference between HIV positive and HIV negative TB patients (P>0.05) in any of the cytokines or chemokines. The median plasma level of IFN-gamma, IL-4, MCP-3, MIP-1betta and IP-10 was significantly different (P<0.05) before treatment and after treatment. Plasma cytokines and chemokines could be used as immunological markers for diagnosing active TB disease and for monitoring effective anti tuberculosis therapy. Acknowledgements We acknowledge the invaluable contribution to this study made by Bamlak Tessema, Sr. Semegne Tesfaye, Sr. Etsegenet Aseffa, Sr. Tigest Gezmu and Sr. Sefina Juhar in recruiting and following study participants. This research is supported by the Bill and Melinda Gates Foundation (BMGF) through Grand Challenges in Global Health (GCGH), grant no. 37772 and the European and Developing Countries Clinical Trial Partnership (EDCTP) through the African European Tuberculosis Consortium (AETBC), grant no.I Keywords: Active tuberculosis, Latent Tuberculosis, differentiation, Cytokiunes, biomarker Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Host-pathogen interactions Citation: Mihret A, Bekele Y, Bobosha K, Kidd M, Aseffa A, Howe R and Walzl G (2013). Plasma cytokines and chemokines differentiate between active and non-active tuberculosis infection. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00289 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 14 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Adane Mihret, Armauer Hansen Research Institute, Addis Ababa, Ethiopia, [email protected] Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Adane Mihret Yonas Bekele Kidist Bobosha Marthin Kidd Abraham Aseffa Rawleigh Howe Gerhard Walzl Google Adane Mihret Yonas Bekele Kidist Bobosha Marthin Kidd Abraham Aseffa Rawleigh Howe Gerhard Walzl Google Scholar Adane Mihret Yonas Bekele Kidist Bobosha Marthin Kidd Abraham Aseffa Rawleigh Howe Gerhard Walzl PubMed Adane Mihret Yonas Bekele Kidist Bobosha Marthin Kidd Abraham Aseffa Rawleigh Howe Gerhard Walzl Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
Source: Frontiers in Immunology
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W2323077176