Year: 2016
Type: article
Abstract: Oral drug delivery systems provide the most convenient, noninvasive, readily acceptable alternatives to parenteral systems. In the current work, eggshell-derived calcium carbonate (CaCO3) nanoparticles were used to develop enteric drug delivery system in the form of tablets. CaCO3nanoparticles were manufactured using top-down ball-milling method and characterized by X-ray diffractometry (XRD) and transmission electron microscopy (TEM) and loaded with 5-fluorouracil as a model drug. Tablets with varying CaCO3core and binder compositions were fabricated and coated with Eudragit S100 or Eudragit L100. Suitability for enteric delivery of the tablets was tested by oral administration to rabbits and radiography. Radiograph images showed that the tablet remained in the stomach of the rabbit for up to 3 hours. Further modifications of these biomaterial-derived nanoparticles and the coatings will enable manufacturing of stable formulations for slow or controlled release of pharmaceuticals for enteric delivery.
Source: Journal of Nanomaterials
DOI: 10.1155/2016/3170248
Authors: Diane Render, Temesgen Samuel, Howard King, Madan Vig, Shaik Jeelani, Ramapuram Jayachandra Babu, Vijaya Rangari
Institutions: Tuskegee University, Auburn University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,375
Awards: Quercetin as an enhancer of the efficacy of 5-FU in mouse models of colon cancer, G4769506169, G4876545192, CENTER FOR BIOMEDICAL RESEARCH, G566951416, G5978228038, NSF-RISE: Enhancement of Research and Educational Infrastructure in Materials Science and Engineering at Tuskegee University, G7869029712, RII: Enhancing Alabama's Research Capacity in Nano/Bio Science and Sensors
OpenAlex ID: W2323334810