Indocyanine Green-Loaded Photoacoustic Nanodroplets: Dual Contrast Nanoconstructs for Enhanced Photoacoustic and Ultrasound Imaging
Year: 2013
Type: article
Abstract: Recently, perfluorocarbon (PFC) nanodroplets were introduced as contrast agents for imaging and image-guided therapy. For example, in sonography, high-intensity ultrasound pulses were used to phase-transition liquid perfluorocarbon to produce gas microbubbles. More recently, perfluorocarbon nanodroplets with encapsulated gold nanorods were used as dual ultrasound/photoacoustic contrast agents. To expedite clinical translation, we synthesized and characterized ICG-loaded perfluorocarbon nanodroplets, i.e., constructs comprising biocompatible, nontoxic and biologically safe materials. We then demonstrated enhanced photoacoustic contrast through optically triggered phase transition of PFC nanodroplets and ultrasound contrast from the resulting PFC bubbles. We assessed the quality enhancement of photoacoustic and ultrasound images through analysis of contrast and contrast-to-noise ratio. We further investigated the changes in image contrast due to increased ambient temperature. Our studies suggest that ICG-loaded perfluorocarbon nanodroplets may become a valuable tool for various imaging modalities, and have promising therapeutic applications.
Source: ACS Nano
DOI: 10.1021/nn403527r
Institution: The University of Texas at Austin
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: Molecular photothermal therapy of cancer using targeted metal nanoparticles, Functional, cellular, and molecular imaging and therapy monitoring using ultrasou, G5984933001, Dual Contrast Agents for Photoacoustic and Ultrasound Imaging, Real-time in vivo IVUS/IVPA imaging to detect and characterize vulnerable plaques, Anatomical, Functional, and Molecular Imaging using Vevo 2100 Ultrasound Scanner
OpenAlex ID: W2323354159