Work

Fluorine-18 Radiochemistry, Labeling Strategies and Synthetic Routes

Year: 2014

Type: review

Abstract: Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET) radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear characteristics (97% β(+) decay, 109.7 min half-life, 635 keV positron energy), along with high specific activity and ease of large scale production, make it an attractive nuclide for radiochemical labeling and molecular imaging. Versatile chemistry including nucleophilic and electrophilic substitutions allows direct or indirect introduction of (18)F into molecules of interest. The significant increase in (18)F radiotracers for PET imaging accentuates the need for simple and efficient (18)F-labeling procedures. In this review, we will describe the current radiosynthesis routes and strategies for (18)F labeling of small molecules and biomolecules.

Source: Bioconjugate Chemistry

DOI: 10.1021/bc500475e

Authors: Orit Jacobson, Dale O. Kiesewetter, Xiaoyuan Chen

Institutions: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: National Institute of Biomedical Imaging and Bioengineering