Work

EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides

Year: 2014

Type: article

Abstract: Most peptides are generally insufficiently permeable to be used as oral drugs. Designing peptides with improved permeability without reliable permeability monitoring is a challenge. We have developed a supercritical fluid chromatography technique for peptides, termed EPSA, which is shown here to enable improved permeability design. Through assessing the exposed polarity of a peptide, this technique can be used as a permeability surrogate.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/ml500239m

Authors: Gilles H. Goetz, Laurence Philippe, Michael J. Shapiro

Institution: Pfizer (United States)

Language: English

Topic: Analytical Chemistry and Chromatography

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

OpenAlex ID: W2323894347

FWCI: 6.41

Cites: 28

Cited by: 167

Related to: 10