Year: 2012
Type: article
Abstract: Pharmacogenetics, and its recent hypostasis Pharmacogenomics, has been in existence as a separate discipline for about five decades. In spite of multiple cases where the pharmacogenetic approaches successfully resolved complex problems of pharmacotherapy, and proved to be beneficial for the patients, we witness its slow integration into medical practice [1]. The basis for Pharmacogenomics is mounted on a solid scientific pedestal, the Human Genome Project. This project brought us an understanding that genetic variability between individual organisms of the same species is a common biological phenomenon, rather than a rare and pitiful deviation from the original plan. Second, we learned that human genome is not stable. Genomic DNA permanently acquires changes and, under certain biological conditions, passes them to the next generations. Therefore, though all 7 billion people on this planet are made up according to the same general blueprint, every single one of us is really unique by multiple parameters including our capacity to acquire, process, and respond to medications.
Author: Evgeny Krynetskiy
Institution: Temple University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2323918559