Work

The dark side of Toll-like receptor signaling

Year: 2014

Type: article

Abstract: Radiation therapy is potentially immunogenic yet it rarely generates long-term antitumor effects. We have recently demonstrated that Toll-like receptor 9 (TLR9) jump-starts the signal transduction and activator of transcription 3 (STAT3)-dependent vascularization and regrowth of tumors that recur upon irradiation. We propose that the targeted inhibition of the TLR9/STAT3 signaling axis in myeloid cells can support the efficacy of local radiotherapy and prevent cancer recurrence.

Source: OncoImmunology

DOI: 10.4161/onci.27894

Authors: Marcin Kortylewski, Sumanta K Pal

Institutions: City Of Hope National Medical Center, Beckman Research Institute

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913