Work

Pharamacodynamic Assessment Shows That CCR5 Surface Expression May Serve As an Indicator for Effective CCR5 Blockade in Allogeneic Stem Cell Transplant (alloSCT) Recipients Treated with Maraviroc

Year: 2015

Type: article

Abstract: Brief CCR5 blockade using maraviroc (MVC) after reduced-intensity alloSCT resulted in a low incidence of acute GvHD and protection against visceral GvHD. We observed significant variability in baseline T-cell CCR5 expression in donors and recipients. We therefore hypothesized that effective blockade of CCR5 activation is dependent on its baseline expression. To test this, we developed a phosphoflow assay that measures the activity of MVC in fresh blood samples.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2014.11.530

Authors: Austin P. Huffman, Lee P. Richman, David L. Porter, Robert H. Vonderheide, Ran Reshef

Institutions: Abramson Cancer Center, University of Pennsylvania

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650