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Glutathione Redox Metabolomic Dysregulation Precedes TNF-α Elevation and Predicts Severity of GVHD in Experimental Transplantation

Year: 2013

Type: article

Abstract: Graft-versus-host disease (GVHD) is characterized by cytokine and chemokine dysregulation that predicts and also contributes to disease severity. Intermediates in sulfur amino acid (SAA) metabolism are known to modulate cytokines implicated in GVHD, such as TNF-a and IL-2. In this first report, plasma and hepatic SAAs and other amino acid metabolite concentrations were sequentially profiled using redox metabolomics assay, in experimental allogeneic bone marrow transplantation (Allo-BMT) models and compared to syngeneic (Syn) BMT.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2012.11.496

Authors: Bindu Kanathezhath, Jung Suh, Swapna Shenvi, Hua Guo, Mark Walters, Bruce Ames

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650

OpenAlex ID: W2324307173

FWCI:

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