Work

Ru-catalysed C–H silylation of unprotected gramines, tryptamines and their congeners

Year: 2016

Type: article

Abstract: Selective Ru-catalysed C2-H silylation of heteroarenes is presented. The transformation works with or without directing group assistance and requires no protecting groups. Gramines and tryptamines may be converted efficiently whilst avoiding deleterious elimination side-reactions. Mechanistic studies reveal an unusual activation of the indole C4-H bond by an electron-rich metal.

Source: Chemical Communications

DOI: 10.1039/c6cc00803h

Authors: K. Devaraj, C. Sollert, C. Juds, P. J. Gates, L. T. Pilarski

Institutions: Uppsala University, University of Bristol

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W2324613499

FWCI: 5.199

Cites: 72

Cited by: 60

Related to: 10