Work

Vicinal Diamination of Alkenes under Rh-Catalysis

Year: 2014

Type: article

Abstract: The synthesis of 1,2-diamines has been achieved through a single-step, tandem sequence involving Rh-catalyzed aziridination followed by NaI-promoted rearrangement to an isomeric cyclic sulfamide. Facile ring opening of these products in hot water and pyridine affords differentially protected vicinal diamines. Demonstration of the utility of this method for the syntheses of (±)-enduracididine and (±)-allo-enduracididine is highlighted.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja506532h

Authors: David E. Olson, Justin Y. Su, D. Allen Roberts, J. Du Bois

Institution: Stanford University

Language: English

Topic: Synthesis and Catalytic Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500