Work

Leukapheresis Safely and Effectively Yields Lymphocyte Populations Sufficient for Chronic Gvhd Research

Year: 2015

Type: article

Abstract: The pathophysiology of chronic Graft-versus-Host Disease (cGVHD) is complex and poorly understood. Storage of peripheral blood mononucleated cells (PBMC) for research in patient cohorts is vital. However, conventional peripheral blood draws are often insufficient for larger scale immunology studies; in particular, cGVHD patients are frequently lymphopenic, which further limits an ability to study the role of relatively rare populations such as Treg cells. To address this limitation, we evaluated the safety of collecting large quantities of lymphocytes in cGVHD patients by steady-state peripheral blood leukapheresis.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2014.11.523