Worth the Weight: Using Inverse Probability Weighted Cox Models in AIDS Research
Year: 2014
Type: article
Abstract: In an observational study with a time-to-event outcome, the standard analytical approach is the Cox proportional hazards regression model. As an alternative to the standard Cox model, in this article we present a method that uses inverse probability (IP) weights to estimate the effect of a baseline exposure on a time-to-event outcome. IP weighting can be used to adjust for multiple measured confounders of a baseline exposure in order to estimate marginal effects, which compare the distribution of outcomes when the entire population is exposed versus when the entire population is unexposed. For example, IP-weighted Cox models allow for estimation of the marginal hazard ratio and marginal survival curves. IP weights can also be employed to adjust for selection bias due to loss to follow-up. This approach is illustrated using an example that estimates the effect of injection drug use on time until AIDS or death among HIV-infected women.
Authors: Ashley L. Buchanan, Michael G. Hudgens, Stephen R. Cole, Bryan Lau, Adaora A. Adimora, for the Women's Interagency HIV Study
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
Awards: K24 Mentoring Junior Faculty: The Minority Imperative, Structural models for treatment and exposure effects in clinical HIV cohorts, Causal Inference in Infectious Disease Prevention Studies, Emory WIHS CRS - Longitudinal Cohort, The Connie Wofsy Women's HIV Study, Brooklyn Women's Interagency HIV Study (WIHS) V, Miami Womens Interagency HIV Study WIHS, WIHS Data Management and Analysis Center (WDMAC), Southern California Women's Interagency HIV Study Consortium, Chicago WIHS Consortium V (CWC), Global Immunological Response to Effective Antiretroviral Therapy (GiREAT:CD4), Washington Women's Interagency HIV/AIDS Study, Clinical and Translational Science Institute, Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, University of North Carolina Womens Interagency HIV Study UNC WIHS, Women's Interagency HIV Study (WIHS-V), UAB-MISS WIHS Cohort, The Johns Hopkins Center for AIDS Research (JHU CFAR), North American AIDS Cohorts on Collaboration and Design (NAACCORD), The University of North Carolina Center for AIDS Research
OpenAlex ID: W2325162617