Work

Total Synthesis of Dixiamycin B by Electrochemical Oxidation

Year: 2014

Type: article

Abstract: N-N-linked dimeric indole alkaloids represent an unexplored class of natural products for which chemical synthesis has no practical solution. To meet this challenge, an electrochemical oxidative dimerization method was developed, which was applied as the pivotal step of the first total synthesis of dixiamycin B. This method is also general for N-N dimerization of substituted carbazoles and β-carbolines, providing entry into seldom explored chemical space.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja5013323

Authors: Brandon R. Rosen, Erik W. Werner, Alexander G. O’Brien, Phil S. Baran

Institution: Scripps Research Institute

Language: English

Topic: Synthesis and bioactivity of alkaloids

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500