Work

Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor

Year: 2000

Type: article

Abstract: There are many types of cerebellar ataxia, including ataxia due to congenital or metabolic disorders and a paraneoplastic form in patients with gynecologic cancer, breast cancer, lung cancer, or Hodgkin's disease.1 This paraneoplastic syndrome is the only type of cerebellar ataxia associated with autoantibodies against neuronal antigens. Often, the neuronal antigens are aberrantly expressed by the tumor cells.2–4 The antineuronal autoantibodies are believed to cause cerebellar ataxia, but this is unproved.5,6 In Hodgkin's disease, the lymphoma precedes the ataxia by months to years in 80 percent of patients, and ataxia often occurs during a prolonged complete remission.4 Among . . .

Source: New England Journal of Medicine

DOI: 10.1056/nejm200001063420104

Authors: Peter Sillevis Smitt, Ayae Kinoshita, Bertie De Leeuw, Wiebe Moll, Michiel Coesmans, Dick Jaarsma, Sonja Henzen-Logmans, Charles Vecht, Chris De Zeeuw, Naohiro Sekiyama, Shigetada Nakanishi, Ryuichi Shigemoto

Institutions: Erasmus MC, Daniel den Hoed Kliniek, Kyoto University, National Institute for Physiological Sciences, Erasmus University Rotterdam

Language: English

Topic: Autoimmune Neurological Disorders and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2325494665

FWCI: 13.33

Cites: 29

Cited by: 450

Related to: 10