Work

Effect of Preexposure to Triazoles on Susceptibility and Virulence of Rhizopus oryzae

Year: 2015

Type: article

Abstract: Triazole prophylaxis has become the norm in patients with hematological malignancies. Breakthrough infections caused by Mucorales during triazole prophylaxis remain a challenging problem. We found that preexposure of Rhizopus oryzae to antifungal triazoles (fluconazole, voriconazole, posaconazole, and itraconazole) did not modify the in vitro susceptibility of Rhizopus oryzae to posaconazole. In contrast, preexposure of Rhizopus to triazoles was associated with the enhanced in vitro susceptibility of R. oryzae to amphotericin B. Preexposure to posaconazole did not alter the virulence of R. oryzae in the fly model of mucormycosis.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01583-15

Authors: Anne-Pauline Bellanger, Nathaniel D. Albert, Russell E. Lewis, Thomas J. Walsh, Dimitrios P. Kontoyiannis

Institutions: The University of Texas MD Anderson Cancer Center, Centre Hospitalier Universitaire de Besançon, Laboratoire Chrono-Environnement, Université de Franche-Comté, IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola, Weill Cornell Medicine, Weill Cornell Medical Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2325704191

FWCI: 0.721

Cites: 19

Cited by: 11

Related to: 10