Pill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults
Year: 2016
Type: article
Study design: Observational Study
Abstract: Prospective memory (PM) is associated with antiretroviral (ARV) adherence in HIV, but little is known about how pill burden and age might affect this association. One hundred seventeen older (≥50 years) and 82 younger (<50 years) HIV-infected adults were administered a measure of PM in the laboratory and subsequently were monitored for ARV adherence for 30 days using the Medication Event Monitoring System. In the older group, better time-based PM performance was associated with higher likelihood of adherence, irrespective of pill burden. Within the younger sample, time-based PM was positively related to adherence only in participants with lower pill burdens. Younger HIV-infected individuals with higher pill burdens may overcome the normal effects of time-based PM on adherence through compensatory medication-taking strategies, whereas suboptimal use of these strategies by younger HIV-infected individuals with lower pill burdens may heighten their risk of ARV nonadherence secondary to deficits in time-based PM.
Authors: David P. Sheppard, Erica Weber, Kaitlin B. Casaletto, Gunes Avci, Steven Paul Woods, Igor Grant, Hampton J. Atkinson, Ronald J. Ellis, Allen J. McCutchan, Thomas D. Marcotte, Jennifer Marquie-Beck, Melanie Sherman, Scott Letendre, Edmund Capparelli, Rachel Schrier, Debra Rosario, Robert K. Heaton, Mariana Cherner, Jennifer E. Iudicello, David J. Moore, Erin E. Morgan, Matthew Dawson, Terry Jernigan, Christine Fennema-Notestine, Sarah L. Archibald, John Hesselink, Jacopo Annese, Michael J. Taylor, Eliezer Masliah, Cristian Achim, Ian Everall, Douglas Richman, David M. Smith, Stuart Lipton, Anthony C. Gamst, Clint Cushman, Ian Abramson, Florin Vaida, Reena Deutsch, Anya Umlauf
Institutions: Kessler Foundation, University of Houston
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Self-Generation of Prospective Memory in HIV-Infected Methamphetamine Users, Prospective Memory in HIV-1 Infection, G4639003361, G7220946635, Neuroimaging and Risk Factor Correlates in Aging and MCI, Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN), HIV Neurobehavioral Research Center
OpenAlex ID: W2325791469