Work

Synthesis of 4,5-dihydro-3,4,4,5,5-pentasubstituted- N-tosyl- 1h-pyrazoles

Year: 2008

Type: article

Abstract: Addition of methyl-or phenyllithium to 3,4,4,5-tetrasubstituted-4//pyrazoles (la-b) smoothly produced the extremely air-sensitive anions of 4,5dihydro-3,4,4,5,5-pentasubstituted-1 //-pyrazoles (2a-c) which were converted to the N-tosylated compounds 3a-c in low to very good yields by reaction with tosyl fluoride.The two-step process is a convenient one-pot route to 4,5-dihydro-N-tosyl-1//-pyrazoles.

Source: Heterocyclic Communications

DOI: 10.1515/hc.2008.14.6.449

Authors: Phong Truong,, G. Davon Kennedy,, Pedro C. Vasquez,, A.L. Baumstark,

Institution: Georgia State University

Language: German

Topic: Synthesis of heterocyclic compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $1,808

Funder: Georgia State University