Spectrophotometric-Assisted Chemometric Method for the Simultaneous Analysis of Furosemide, Carbamazepine, Diazepam, and Carvedilol in Their Bulk and Marketed Formulation
Year: 2016
Type: article
Abstract: Simultaneous determination of Furosemide, Carbamazepine, Diazepam, and Carvedilol in bulk and pharmaceutical formulation using the partial least squares regression (PLS-1 and PLS-2) is described in this study.The two methods were successfully applied to estimate the four drugs in their quaternary mixture using UV spectral data of 84synthetic mixtures in the range of 200-350nm with the intervals ∆λ=0.5nm.The linear concentration range were 1-20 µg.mL -1 for all, with correlation coefficient (R 2 ) and root mean squares error for the calibration (RMSE) for FURO, CARB, DIAZ, and CARV were 0.9996, 0.9998, 0.9997, 0.9997, and 0.1128, 0.1292, 0.1868,0.1562respectively for PLS-1, and for PLS-2 were 0.9995, 0.9999, 0.9997, 0.9998, and 0.1127, 0.1205, 0.1691, and 0.1686 respectively.Satisfactory results were achieved with applying PLS-1 and PLS-2 in the determination of the cited drugs in their pharmaceutical formulations and a good agreement was found between the proposed methods.
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2325942021