Work

Dietary tocotrienol/gamma-cyclodextrin complex increases mitochondrial membrane potential and ATP concentrations in the brain of aged mice

Year: 2016

Type: article

Abstract: Brain aging is accompanied by a decline in mitochondrial function. In vitro studies suggest that tocotrienols, including gammaand delta-tocotrienol (T3), may exhibit neuroprotective properties [1]. However little is known about the effect of dietary T3 on mitochondrial function in vivo. In this study we monitored the effect of a dietary T3/gamma-cyclodextrin complex (T3CD) on mitochondrial membrane potential and ATP levels in the brain (cortex) of 21 month old aged mice. Mice were fed either control diet or a diet enriched with T3CD providing 100 mg T3 per kg diet for 6 months. Dietary T3CD significantly increased mitochondrial membrane potential and ATP levels as compared to controls. The increase of MMP and ATP due to dietary T3CD was accompanied by an increase in the protein levels of the mitochondrial transcription factor A (TFAM). Furthermore dietary T3CD slightly increased mRNA levels of superoxide dismutase, gamma-glutamyl cysteinyl synthetase and heme oxygenase 1 in the brain. Overall, present data suggest that T3CD increases TFAM, mitochondrial membrane potential and ATP synthesis in the brain of aged mice.

Source: Federal Research Centre for Cultivated Plants (Julius Kühn-Institut)

Authors: Anke Schloesser, Naoko Ikuta, Leiji Terao, Seiichi Matsugo, Gerald Rimbach

Institutions: Christian-Albrechts-Universität zu Kiel, Kobe University, Kanazawa University

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2326500585

FWCI:

Cites: 21

Cited by:

Related to: 10