Brief Report: APOL1 Renal Risk Variants Are Associated With Chronic Kidney Disease in Children and Youth With Perinatal HIV Infection
Year: 2016
Type: article
Study design: Observational Study
Abstract: APOL1 renal risk alleles are associated with chronic kidney disease (CKD) in adults, with the strongest effect being for HIV-associated nephropathy. Their role in youth with perinatal HIV-1 infection (PHIV) has not been studied. In a nested case-control study of 451 PHIV participants in the Pediatric HIV/AIDS Cohort Study, we found a 3.5-fold increased odds of CKD in those carrying high-risk APOL1 genotypes using a recessive model [95% confidence interval (CI): 1.2 to 10.0]. We report an unadjusted incidence of 1.2 CKD cases/100 person-years (95% CI: 0.5 to 2.5) in PHIV youth carrying APOL1 high-risk genotypes, with important implications for sub-Saharan Africa.
Authors: Murli U. Purswani, Kunjal Patel, Cheryl A. Winkler, Stephen A. Spector, Rohan Hazra, George R. Seage, Lynne Mofenson, Brad Karalius, Gwendolyn B. Scott, Russell B. Van Dyke, Jeffrey B. Kopp, for the Pediatric HIV/AIDS Cohort Study
Institutions: Bronx-Lebanon Hospital Center, Albert Einstein College of Medicine, Harvard University, National Cancer Institute, Center for Cancer Research, Leidos Biomedical Research Inc. (United States), University of California San Diego, Rady Children's Hospital-San Diego, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, University of Miami, Tulane University, National Institute of Diabetes and Digestive and Kidney Diseases
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2326543433