Year: 2011
Type: article
Abstract: Structure determination by the sulfur-SAD (single wavelength anomalous scattering) method is gaining considerable interest in the community.The technique offers the advantage of structure determination from data collected on native crystals using the weak sulfur anomalous scattering signal.To increase the success rate of the S-SAD structure determination we have studied several approaches, in addition to using longer wavelength X-rays, for enhancing the anomalous scattering signal-to-noise ratio (S/ N) contained in the S-SAD data set.These approaches include: 1 Data averaging from multiple crystals. The collection of multiple (lower exposure) data sets (MDS) fromthe same crystal for a given total X-ray dose, which are processed together to give the phasing data set.3. The use of highly "sensitive" X-ray area detectors.We are also developing a database (the SSAD_DB) aimed at documenting all experimental information related to the successful sulfur-SAD phasing experiment for future data mining and archival.Examples and results from these studies and details of the SSAD_DB will be presented.
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2326967713