Genome-Wide Association Study of Cause-Specific Transplant-Related Mortality (TRM) after HLA-Matched Unrelated Donor Allogeneic BMT for Acute Leukemia or Myelodysplastic Syndrome Demonstrates Unique, Non-Overlapping Genetic Associations (Discovery-BMT)
Year: 2016
Type: article
Study design: Observational Study
Abstract: TRM is a limitation for curative URD-BMT. We performed a genome-wide association study , named DISCOVeRY-BMT (Determining the Influence of Susceptibility COnveying Variants Related to one-Year mortality after BMT) of 1-year TRM in 3,532 patients treated for AML, ALL or MDS (recipients) reported to CIBMTR from 2000-2011 and their 8/8 HLA-matched URD (donors); donor DNA was available for 98% of HCT recipients. Cohorts 1 and 2, had 2,240 and 823 donor-recipient pairs respectively, and were genotyped using the Illumina HumanOmniExpress-24 BeadChip containing 729,293 single nucleotide polymorphisms (SNPs).
Authors: Theresa E. Hahn, Leah Preus, Philip L. McCarthy, Marcelo C. Pasquini, Kenan Onel, Xiaochun Zhu, Stephen Spellman, Christoper Haiman, Daniel O. Stram, Loreall Pooler, Xie Sheng, Qianqian Zhu, Li Yan, Qian Liu, Qiang Hu, Song Liu, Alyssa Clay, Sebastiano Battaglia, David Tritchler, Lara Sucheston-Campbell
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2327434775