Work

Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia

Year: 2015

Type: editorial

Abstract: Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2015.1087452

Authors: Lee Sooyeon, Kristina L. Go, Jae-Sung Kim

Institution: University of Florida

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases