Year: 2001
Type: review
Abstract: The New Eng land Jour nal of Medicine Creutzfeldt-Jakob disease is approximately 1 case per 1 million population, 23 but among persons between the ages of 60 and 74 years, the incidence is nearly 5 per 1 million. 24Cases in patients as young as 17 years and as old as 83 have been recorded. 23,25Creutzfeldt-Jakob disease is relentlessly progressive and usually causes death within a year after its onset.Each geographic cluster of cases of prion disease was initially thought to be a manifestation of viral communicability, 26 but each was later shown to be due to a PRNP gene mutation except for new variant Creutzfeldt-Jakob disease.
Source: New England Journal of Medicine
Author: Stanley B. Prusiner
Institution: University of California, San Francisco
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2327641970