Work

Parsing psychosis subtypes through investigations of rare genetic variants

Year: 2016

Type: article

Abstract: While we have now identified >100 common single nucleotide polymorphisms (SNPs) contributing to risk for the umbrella diagnosis of schizophrenia (Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014), the genetic contribution to variation in clinical expression for schizophrenia is far less clear. Most prior work in this area has focused on common variants (Bergen et al., 2009; Fanous and Kendler, 2008), often in selected candidate genes, although, some recent studies have used genome-wide association studies (GWAS) to investigate symptom variation in schizophrenia (Docherty et al., 2015; Bergen et al., 2014; Edwards et al., 2016; Fanous et al., 2012).

Source: EBioMedicine

DOI: 10.1016/j.ebiom.2016.04.009

Author: Sarah E. Bergen

Institutions: Broad Institute, Karolinska Institutet, Stanley Center for Psychiatric Research

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,780