Work

Absolute Structures of Monoterpenoids with a δ-Lactone-Containing Skeleton from Ligularia hodgsonii

Year: 2012

Type: article

Abstract: Bioactivity-directed fractionation of a methanol extract of Ligularia hodgsonii afforded two new monoterpenoids, liguhodgcins A (1) and B (2), with an unusual δ-lactone-containing skeleton. Moreover, liguhodgcin A (1) contained a chlorine atom. The structures and absolute configurations of the two compounds were elucidated using NMR spectroscopy, X-ray crystallography, ECD data, and computational approaches. A probable biosynthesis pathway to 1 and 2 was also proposed and discussed. The cytotoxicity of compounds 1 and 2 was evaluated against the human leukemia (HL-60), human hepatoma (SMMC-7721), and human cervical carcinoma (HeLa) cell lines.

Source: Journal of Natural Products

DOI: 10.1021/np200693z

Authors: Jian-Jun Chen, Wen-Xian Li, Kun Gao, Xiao-Jie Jin, Xiao-Jun Yao

Institutions: State Key Laboratory of Applied Organic Chemistry, Lanzhou University

Language: English

Topic: Sesquiterpenes and Asteraceae Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2327939626

FWCI: 0.567

Cites: 15

Cited by: 20

Related to: 10