Work

Direct Access to Functionalized Azepanes by Cross-Coupling with α-Halo Eneformamides

Year: 2014

Type: article

Abstract: The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the coupling products were obtained.

Source: Organic Letters

DOI: 10.1021/ol403671s

Authors: Timothy K. Beng, Sidney M. Wilkerson-Hill, Richmond Sarpong

Institutions: University of California System, University of California, Berkeley

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Institutes of Health, National Institute of General Medical Sciences