Lung Cancer in SLE: An Update
Year: 2014
Type: article
Study design: Observational Study
Abstract: Objective: An increased lung cancer risk in systemic lupus erythematosus (SLE) has been previously suggested. Our objective was to provide an updated analysis of the lung cancer cases from a multi-site international cohort study, including descriptive statistics of the demographics (age, sex, and race/ethnicity) of cases, as well as the histology. Materials and Methods: Data were obtained from an SLE sample of 16,409 SLE patients across 30 centers. Cancer occurrence was ascertained through linkages with regional tumor registries. Results: We analyzed 85 lung cancers that had occurred across eight countries. The average age of the SLE patients at lung cancer diagnosis was 60 years and the majority (83.5%) of these cases was female. The average SLE duration at the time of cancer diagnosis was 11 years. Histological type was specified in 32 cases with adenocarcinoma reported as the most common histological type (N=16), followed by squamous cell carcinoma (N=8)and small cell cancer (N=6) and adenosquamous cancers (2). Conclusion: Our results suggest a similar histological distribution of lung cancers in SLE to that of lung cancer in the general population with a possibly increasing proportion of squamous cell carcinomas. Keywords: Lung cancer, systemic lupus erythematosus, Malignancy. Read more →
Author: S. Bernatsky
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2328459215