Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors
Year: 2016
Type: article
Abstract: Development of heat shock protein 90 (Hsp90) C-terminal inhibitors has emerged as an exciting strategy for the treatment of cancer. Previous efforts have focused on modifications to the natural products novobiocin and coumermycin. Moreover, variations in both the sugar and amide moieties have been extensively studied, whereas replacements for the coumarin core have received less attention. Herein, 24 cores were synthesized with varying distances and angles between the sugar and amide moieties. Compounds that exhibited good anti-proliferative activity against multiple cancer cell lines and Hsp90 inhibitory activity, were those that placed the sugar and amide moieties between 7.7 and 12.1 Å apart along with angles of 180°.
Source: Chemistry - A European Journal
Authors: Katherine M. Byrd, Chitra Subramanian, Jacqueline Sanchez, Hashim F. Motiwala, Weiya Liu, Mark S. Cohen, Jeffrey Holzbeierlein, Brian S. J. Blagg
Language: English
Topic: Heat shock proteins research
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: National Cancer Institute
OpenAlex ID: W2328675759