Work

Optimization of Drug-Like Properties of Nonsteroidal Glucocorticoid Mimetics and Identification of a Clinical Candidate

Year: 2014

Type: article

Abstract: A series of nonsteroidal "dissociated" glucocorticoid receptor agonists was optimized for drug-like properties such as cytochrome P450 inhibition, metabolic stability, aqueous solubility, and hERG ion channel inhibition. This effort culminated in the identification of the clinical candidate compound ( R )-39.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/ml500387y

Authors: Christian Harcken, Doris Riether, Pingrong Liu, Hossein Razavi, Usha Patel, Thomas Lee, Todd Bosanac, Yancey Ward, Mark Ralph, Zhidong Chen, Donald Souza, Richard M. Nelson, Alison Kukulka, Tazmeen N. Fadra-Khan, Ljiljana Zuvela-Jelaska, Mita Patel, David S. Thomson, Gerald H. Nabozny

Institution: Boehringer Ingelheim (United States)

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2328847243

FWCI: 2.754

Cites: 21

Cited by: 26

Related to: 10