Work

A metabolic link between the urea cycle and cancer cell proliferation

Year: 2016

Type: article

Abstract: Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation. Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.

Source: Molecular & Cellular Oncology

DOI: 10.1080/23723556.2015.1127314

Authors: Sandesh C.S. Nagamani, Ayelet Erez

Institutions: Baylor College of Medicine, Texas Children's Hospital, Weizmann Institute of Science

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Doris Duke Charitable Foundation, Intellectual and Developmental Disabilities Research Center