Work

Demineralized Bone Matrix Incorporated PLGA Matrices

Year: 2006

Type: conference-paper

Abstract: Poly(lactic-co-glycolic acid)-PLGA (85:15) films incorporated with demineralized bone matrix (DBM) powder with the weight ratio of polymer: DBM (75:25) were investigated for release of agents including osteoinductive (OI) factors during the 80 day period exposing to Phosphate Buffered Saline (PBS) at 37 °C. The release amount of agents including OI factors from DBM/PLGA matrices were more than 2-fold higher at 70 days than at 10 days, respectively. This result demonstrated that controlled release of OI factors can be achieved for extended time period at target site using PLGA as a carrier for DBM powder. Murine Bone Marrow Stromal Cell (BMSC) attachment was studied with different time points at 30 min, 1 h, 2 h, 4 h, 6 h and 24 h for DBM/PLGA and PLGA control matrices. Significantly higher number of BMSCs was attached to the DBM/PLGA matrices at each time points compared with controls. This result suggests that BMSCs favor to attach the surfaces having OI properties. If DBM is incorporated into biodegradable 3-D polymer scaffolds and culture with BMSCs, those scaffolds could be potentially used for bone tissue engineering applications.

Source: Applied Mechanics

DOI: 10.1115/imece2006-14796

Authors: A. Champa Jayasuriya, Elisabeth Michels, Nabil A. Ebraheim

Institution: University of Toledo

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,448