e0325 Influence of probucol on endothelial dependent vasodilation reaction in patients with acute coronary syndrome
Year: 2010
Type: conference-abstract
Abstract: Objective The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy. Methods 51 ACS patients were divided randomly into a probucol treatment group (p) and a routine treatment group (C). Oxidised low-density lipoprotein (ox-LDL) was measured in peripheral blood by Sandwich ELISE method. The brachial arterial hyperaemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilation were measured by high resolution ultrasound. These variables were analysed after received probucol 3 months. Results The level of FMD with probucol treatment group was significantly increased after 3 months compared to pretreamented (p<0.05), while the level of ox-LDL in peripheral blood in ACS patients was markedly diseased (p<0.01). The FMD with probucol treatment group was significantly increased compared to ACS routine treatment group (p<0.05), while the level of ox-LDL was markedly desaesed (p<0.01). The linear correlation analysis showed that plasma ox-LDL was a negative correlation with FMD in after treatmented patients by probucol with ACS (r=−0.517, p<0.001). Conclusions It was important that vascular endothelial function and endothelial dependent vasodilation reaction may be improved in the ACS patients of after the antioxidant probucol therapy.
Source: Heart
Authors: Hong-Mei Dong, Lan Huang, Yao-Ming Song, Ai-Min Li, Jun Jin, Gang Zhao, Chun-Mei Lin, Chun-rong Tao
Institutions: Army Medical University, Xinqiao Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2329520562