Comparison of the Methods of Diagnosis of Bacterial Vaginosis
Year: 2011
Type: article
Study design: Observational Study
Abstract: Background and Objective: Although Nugent’s criterion is
considered as the gold standard, routinely a combination of
various methods is used for the diagnosis of bacterial vaginosis.
In the present study we compared culture, Spiegel’s criteria
and Amsel’s criteria with Nugent’s method for the diagnosis of
bacterial vaginosis.
Materials and Methods: Five hundred and twenty seven
women who attended the Government Maternity Hospital
and a tertiary care centre in south India for antenatal care or
forany other complaint formed the study population. Diagnosis
of bacterial vaginosis was done by culture, Amsel’s, Nugent’s
and Spiegel’s criteria. The positive predictive value, the negative
predictive value and the sensitivity and specificity of these
methods,in comparison with Nugent’s criteria, by considering it
as the gold standard, were calculated. Statistical analysis was
done by using the Chi Square test or the Fisher’s exact test as
was appropriate.
Results: In comparison with Nugent’s criteria, the positive
predictive value, negative predictive value and the sensitivity
and specificity of Amsel’s criteria were 80.4%, 94.8%, 78% and
95.6% and that of Spiegel’s criteria were 77.5%, 100%, 100%
and 93.2%. The culture was 51% sensitive and 88.7% specific,
the positive predictive value was 85.5% and the negative
predictive value was 58%. We diagnosed 100 (19%) casesof
bacterial vaginosisby Nugent’s method,129 (24%) casesby
Spiegel’s method,97 (18%) cases by Amsel’s criteria and 88
(16.7%) cases by culturing.
Conclusion: Amsel’s and Spiegel’s criteria were comparable
with Nugent’s criteria for the diagnosis of bacterial vaginosis.
Diagnosis of bacterial vaginosis by culture was least sensitive
method.
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $275
OpenAlex ID: W2329567894