Work

Schistosoma mansoni-New Zealand Rabbit Model: Resistance Induced by Infection Followed by Active Immunization with Protective Antigens

Year: 1991

Type: article

Abstract: In previous studies, rabbits immunized with adult worm antigens released from fresh adult schistosomes incubated in saline media showed a significant level of protection against challenge parasites. Focusing on the rabbit-Schistosoma mansoni model, concomitant immunity was investigated. A peculiar form of response to cercarial infection was observed: rabbits subjected to percutaneous infection and similar reinfections at different times after primary infection killed schistosomula from the challenge infection as well as established parasites from the primary infection. In this study the challenge infection stimulus was replaced by active immunization with an adult worm-derived protective antigenic mixture. The results show that immunization of New Zealand rabbits with an adult worm antigenic extract is capable of inducing a response that results in a significant reduction of the mean worm burden of the primary infection earlier than did homologous infection, as compared to worm reduction due to a second infection.

Source: Journal of Parasitology

DOI: 10.2307/3282571

Authors: Miriam Tendler, Marilia S. S. Almeida, Roberto Magalhaes Pinto, Dely Noronha, Naftale Katz

Institutions: Instituto Oswaldo Cruz, Fundação Oswaldo Cruz

Language: English

Topic: Parasites and Host Interactions

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Georgia, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Oswaldo Cruz