Work

Structure of complement C6 suggests a universal model for pore formation by cytolysins

Year: 2011

Type: article

Abstract: MSaccelaration activity" or by binding protease factor I in "co-factor activity" to degrade C3b into inactive iC3b [7].Non-protected labelled surface, on the other hand, trigger the terminal pathway of complement activation, which is started by cleavage of C5 (a homologue of C3) into C5b and association with MAC-protein C6 into C5b6.C5b6 in turn binds other MAC proteins C7, C8 [8] and multiple C9s causing MAC formation and cell lysis.

Source: Acta Crystallographica Section A Foundations of Crystallography

DOI: 10.1107/s010876731109708x

Authors: A. E. Aleshin, I. U. Schraufstatter, L. A. Bankston, R. G. DiScipio, R. C. Liddington

Institution: The University of Queensland

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2329697322

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