Work

Metastasizing and Non-Metastasizing Tumors Likely Evolve from DNA Phenotypes via Independent Pathways

Year: 2004

Type: article

Abstract: We have recently discovered, using statistical models of Fourier transform-infrared spectra, two distinct cancer DNA phenotypes in histologically normal tissues surrounding non-metastasizing primary tumors and tumors with evidence of distant metastases. Structural comparisons of the DNA from these tumor types imply that each evolves via a separate pathway from DNA phenotypes originating in progenitor cells. These findings challenge the widely-held concept of metastasis.

Source: Cell Cycle

DOI: 10.4161/cc.3.10.1169

Author: Donald C. Malins

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2329792054

FWCI: 0.387

Cites: 21

Cited by: 3

Related to: 10