Phytochemical evaluation and investigations in to sedative properties of Datura stramonium (Linn) seeds in experimental mice
Year: 2014
Type: article
Abstract: Datura stramonium L is used as a sedative for the management of insomnia, and the seeds have long been used as drug of abuse by the young people for hallucination purpose.The present study was designed to investigate the sedative properties of seeds extract of D. stramonium using animal model.Diazepam-induced sleeping time test was used in this investigation.Phytochemical screening of the aqueous seed extract shows the presence of Tannins, cardiac glycosides, anthraquinones, saponins, triterpenes, flavonoids as well as alkaloids.The seeds extract of D. stramonium significantly (p<0.01)increased the duration of sleep induced by diazepam at a dose of 40 and 80mg/kg b.wt.In conclusion, the results of our current investigations revealed that D. stramonium may possess sedative properties which support the use of the seeds extract for the management of insomnia.
Author: Malami I
Institution: Usmanu Danfodiyo University
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2329794424