Biochemical Studies on the Drug Metabolism. I. Some Factors Affecting on the Metabolism of Cyclobarbital
Year: 1962
Type: article
Abstract: Some factors affecting on the metabolism of cyclobarbital (EHB) by the rat liverpreparation were examined.Sex difference was especially shown in the formation of 3-OH-EHB, but no difference in that of 3-keto-EHB was shown.The pretreatment of female rats with EHB enhanced both the formation of 3-OHEHB and that of 3-keto-EHB in approximately same proportion as controls. However, the pretreatment with 3-OH-EHB increased the formation of 3-OH-EHB and decreased that of 3-keto-EHB from EHB. The conversion of 3-OH-EHB to 3-keto-EHB was depressed by the pretreatment with testosterone or 3-OH-EHB. On the other hand, the conversion of 3-keto-EHB to 3-OH-EHB was stimulated by such a treatment. Another metabolite of EHB, 3-keto-EHB, has not stimulatory effect on the EHB-metabolism.The removal of the adrenal glands did not prevent the stimulatory effect of EHB.
DOI: 10.1248/cpb.10.952
Authors: Eigo Takabatake, Toshihiko Ariyoshi
Institutions: University of Nagasaki, Nagasaki University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2330076391