Year: 2016
Type: article
Abstract: To the Editor: It is unclear whether circulating free or bioavailable 25-hydroxyvitamin D is a better marker of vitamin D status than is total 25-hydroxyvitamin D, especially in racially diverse populations. Until recently, the only method to compare the levels was to estimate the level of free or bioavailable 25-hydroxyvitamin D from total 25-hydroxyvitamin D, vitamin D-binding protein (also known as gc-globulin, encoded by the GC gene), and albumin, with or without the GC genotype. Powe et al. reported that levels of vitamin D-binding protein, as measured on a monoclonal enzyme-linked immunosorbent assay (ELISA, R&D Systems), were lower in black . . .
Source: New England Journal of Medicine
DOI: 10.1056/nejmc1513502
Authors: Carrie M. Nielson, Kerry S. Jones, Rene F. Chun, Jon Jacobs, Ying Wang, Martin Hewison, John S. Adams, Christine M. Swanson, Christine G. Lee, Dirk Vanderschueren, Steven Pauwels, Ann Prentice, Richard D. Smith, Tujin Shi, Yuqian Gao, Joseph M. Zmuda, Jodi Lapidus, Jane A. Cauley, Roger Bouillon, Inez Schoenmakers, Eric S. Orwoll
Institutions: Oregon Health & Science University, MRC Elsie Widdowson Laboratory, Medical Research Council, University of California, Los Angeles, KU Leuven, Pacific Northwest National Laboratory, University of Birmingham, University of Colorado Denver, Portland VA Medical Center, University of Pittsburgh
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2330175379