Work

Pharmacogenetic Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplants

Year: 2014

Type: article

Abstract: Invasive fungal infections are a significant cause of morbidity and mortality in recipients of hematopoietic cell transplantation (HSCT), warranting antifungal prophylaxis as a standard of care in these patients. Due to its broad spectrum activity and multiple available dosage forms, voriconazole remains one of the commonly used agents in this setting. Voriconazole is known to have wide inter- and intra-patient variability in levels. Additionally these levels are affected by a common CYP450 polymorphism, CYP450-2C19.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2013.12.132