The squalestatings, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
Year: 1992
Type: article
Abstract: During the screening of fungi for inhibitors of squalene synthase, Phomasp.C2932 was found to produce three structurally related novel inhibitors.These compounds,designated the squalestatins, exhibited potent activity against both mammalian (rat liver) and fungal {Candida albicans) squalene synthase.Furthermore, they also had broad spectrum in vitro antifungal activity.High serum cholesterol levels have been established as an important risk factor for atherosclerosis, and cholesterol lowering regimens have been shown to decrease the incidence of coronary heart disease morbidity and mortality1'2).In the search for agents which may lower cholesterol levels,
Source: The Journal of Antibiotics
Authors: MICHAEL J. DAWSON, JOHN E. FARTHING, PETER S. MARSHALL, ROBERT F. MIDDLETON, MELANIE J. O''NEILL, ALAN SHUTTLEWORTH, CHARI STYLLI, R. MURRAY TAIT, PAM M. TAYLOR, HOWARD G. WILDMAN, ANTONY D. BUSS, DAVID LANGLEY, MICHAEL V. HAYES
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2330206990