IMMUNOHISTOLOGICAL STUDY OF THE p53 EXPRESSION AND THE CELL PROLIFERATING ACTIVITY IN INVASIVE DUCTAL ADENOCARCINOMA OF THE PANCREAS
Year: 1999
Type: article
Study design: Observational Study
Abstract: Forty-three resected materials of invasive ductal adenocarcinoma of the pancreas were examined for the expression of p 53 protein and the cell proliferating activity in comparison with the clinicopathological factors and prognosis. Anti-p 53 antibody (DO-7) and anti-Ki-67 antibody (MIB-1) were used as the primary antibody. Although a univariate analysis revealed significant variants including pancreatic cut end (pw). and p 53 protein expression (p<0.05), none of these were independent prognostic indicator according to a multivariate analysis. With regard to the clinicopatholigical factors, p 53 protein expression was significantly associated with tumor size (ts), arterial invasion (a), venous invasion (v), intrapancreatic nerve invasion (ne), lymph node metastasis, invasion to the dissected pancreatic tissue (ew), and pw (p<0.05). Furthermore, p 53 expression was correlated with the cell proliferating activity (p=0.039). With regard to the recurrent pattern, p 53 protein expression was associated with the recurrence as hepatic metastasis (p=0.041). As a result, while the significance of p 53 protein expression was not important as a prognostic indicator, the involvement of p53 protein expression with the local progression, proliferating activity, and hepatic metastasis was suggested in invasive ductal adenocarcinoma of the pancreas.
DOI: 10.3919/jjsa.60.2044
Institution: Jikei University School of Medicine
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2330307611