249Activity of Plazomicin Against Contemporary Isolates of Enterobacteriaceae from New York City
Year: 2014
Type: conference-abstract
Abstract: Background. Plazomicin is a next generation aminoglycoside that is not affected by most commonly-encountered aminoglycoside modifying enzymes and is currently being studied in a global Phase 3 trial enrolling patients with bloodstream infections or nosocomial pneumonia due to carbapenem-resistant Enterobacteriaceae. The activity of this novel agent was tested against a contemporary collection of Enterobacteriaceae from New York City. Methods. Unique patient isolates of Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp. were gathered from 11 hospital microbiology laboratories from November 2013 through January 2014. Isolates underwent susceptibility testing by the agar dilution method according to CLSI guidelines. Cephalosporin-resistant isolates were screened for the presence of blaKPC. Results. A total of 2866 isolates of E. coli (two with blaKPC), 944 isolates of K. pneumoniae (125 with blaKPC), and 216 isolates of Enterobacter spp. (7 with blaKPC) were collected. Susceptibility results for gentamicin, amikacin, and plazomicin are shown in the table. Among the 125 isolates of K. pneumoniae with blaKPC, the MIC50 and MIC90 values for plazomicin were 0.5 and 1 µg/ml, respectively. Conclusion. Plazomicin is an investigational aminoglycoside with broad-spectrum activity against common Enterobacteriaceae, including multidrug-resistant strains of K. pneumoniae. Further studies with this agent are warranted. Disclosures. C. Urban, Pfizer: Speaker's Bureau, Speaker honorarium; Cubist: Speaker's Bureau, Speaker honorarium D. Landman, Tetraphase: Research Contractor, Research grant; Achaogen: Research Contractor, Research grant J. Quale, Tetraphase: Research Contractor, Research grant; Achaogen: Research Contractor, Research grant.
Source: Open Forum Infectious Diseases
Language: English
Subfield: Molecular Medicine
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W2330913268