Work

Redox-Activated Manganese-Based MR Contrast Agent

Year: 2013

Type: article

Abstract: Here we report a simple Mn coordination complex with utility as a redox-sensitive MR probe. The HBET ligand stabilizes both the Mn(2+) and Mn(3+) oxidation states. In the presence of glutathione (GSH), low relaxivity Mn(III)-HBET is converted to high relaxivity Mn(II)-HBET with a 3-fold increase in relaxivity, and concomitant increase in MR signal. Alternately, hydrogen peroxide can convert Mn(II)-HBET to Mn(III)-HBET with a reduction in MR signal.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja312610j

Authors: Galen S. Loving, Shreya Mukherjee, Peter Caravan

Institutions: Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging

Language: English

Topic: Lanthanide and Transition Metal Complexes

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: National Cancer Institute, National Center for Research Resources

Awards: Cancer Imaging, Center for Functional Imaging Technologies, 500 MHz NMR Spectrometer for Molecular Imaging Applications, Activatable MR Imaging Probes